Breimer, Douwe D. : rechercher sur Z-Library

Ewoud J. van Hoogdalem, Albertus G. de Boer, Douwe D. Breimer

Année:

1991

Langue:

english

Fichier:

PDF, 560 KB

english, 1991

Intestinal drug absorption enhancement: An overview

Journal:

Pharmacology & Therapeutics

Année:

1989

Langue:

english

Fichier:

PDF, 3.08 MB

english, 1989

Pharmacokinetics of Rectal Drug Administration, Part I

van Hoogdalem, Ewoud J., de Boer, Albertus G., Breimer, Douwe D.

Journal:

Clinical Pharmacokinetics

Année:

1991

Langue:

english

Fichier:

PDF, 1.59 MB

english, 1991

Pharmacokinetics of Rectal Drug Administration, Part II

van Hoogdalem, Ewoud J., de Boer, Albertus G., Breimer, Douwe D.

Journal:

Clinical Pharmacokinetics

Année:

1991

Langue:

english

Fichier:

PDF, 1.97 MB

english, 1991

Eureka! (European Research Universities and the Challenges of the 21st Century) || Contents

Provoost, Frank, van Santen, Hester, Weijts, Christiaan, Breimer, Douwe, Bremmer, David, Funnekotter, Bart

Année:

2005

Fichier:

PDF, 42 KB

2005

Complete rectal absorption of theophylline in rats without absorption enhancer

Ewoud J. van Hoogdalem, Albertus G. de Boer, Douwe D. Breimer

Journal:

Yoshiteru Watanabe, Ewoud J. van Hoogdalem, Albertus G. de Boer, Douwe D. Breimer

Année:

1986

Langue:

english

Fichier:

PDF, 246 KB

english, 1986

Absorption enhancement of rectally infused cefoxitin by medium chain monoglycerides in conscious rats

Journal:

Ewoud J. van Hoogdalem, Marlene A. de Best, Albertus G. de Boer, Douwe D. Breimer

Année:

1988

Langue:

english

Fichier:

PDF, 320 KB

english, 1988

Variable effects of laurocapram (azone) on rectal cefoxitin absorption in rats

Journal:

Ewoud J. van Hoogdalem, Christl Vermeij-Kerrs, Albertus G. de Boer, Douwe D. Breimer

Année:

1989

Langue:

english

Fichier:

PDF, 212 KB

english, 1989

Topical effects of absorption enhancing agents on the rectal mucosa of rats in vivo

Journal:

Joost B. M. M. Van Bree, Jan W. Van Nispen, J. Coos Verhoef, Douwe D. Breimer

Année:

1990

Langue:

english

Fichier:

PDF, 1.36 MB

english, 1990

Development of specific antisera against 9-desglycinamide-8-arginine vasopressin by site-specific immunization

Journal:

Tuk, Bert, Oberyé, Janine J. L., Pieters, Monique S. M., Schoemaker, Rik C., Kemp, Bob, van Gerven, Joop, Danhof, Meindert, Kamphuisen, Hilbert A. C., Cohen, Adam F., Breimer, Douwe D., Peck, Carl C.

Année:

1991

Langue:

english

Fichier:

PDF, 421 KB

english, 1991

Pharmacodynamics of temazepam in primary insomnia: Assessment of the value of quantitative electroencephalography and saccadic eye movements in predicting improvement of sleep

Journal:

Jan H.M. Schellens, Hans H.F. Van Der Wart, Jan Willem Hoevers, Douwe D. Breimer

Année:

1997

Langue:

english

Fichier:

PDF, 820 KB

english, 1997

Gas chromatographic determination of sparteine and 2- and 5-dehydrosparteine in plasma and urine

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Année:

1988

Langue:

english

Fichier:

PDF, 447 KB

english, 1988

PK/PD Modelling and Beyond: Impact on Drug Development

Douwe D. Breimer

Journal:

de Leede, Leo G J, Hug, Carl C, de Lange, Simon, de Boer, Albertus G, Breimer, Douwe D

Année:

2008

Langue:

english

Fichier:

PDF, 77 KB

english, 2008

Rectal and intravenous propranolol infusion to steady state: Kinetics and β-receptor blockade

Journal:

Van Harten, Jaap, van Brummelen, Peter, Lodewijks, Michiel ThM, Danhof, Meindert, Breimer, Douwe D

Année:

1984

Langue:

english

Fichier:

PDF, 569 KB

english, 1984

Pharmacokinetics and hemodynamic effects of nisoldipine and its interaction with cimetidine

Journal:

van Harten, Jaap, Burggraaf, Jacobus, Ligthart, Gerard J, van Brummelen, Peter, Breimer, Douwe D

Année:

1988

Langue:

english

Fichier:

PDF, 691 KB

english, 1988

Single- and multiple-dose nisoldipine kinetics and effects in the young, the middle-aged, and the elderly

Journal:

Année:

1989

Langue:

english

Fichier:

PDF, 552 KB

english, 1989

The influence of infusion rate on the hemodynamic effects of felodipine

Cohen, Adam F, van Hall, Maureen A, van Harten, Jaap, Schoemaker, Rik C, Johansson, Pehr, Breimer, Douwe D, Visser, Rian, Edgar, Bo

Journal:

Schellens, Jan H M, Ghabrial, Hany, van der Wart, Hans H F, Bakker, Eke N, Wilkinson, Grant R, Breimer, Douwe D

Année:

1990

Langue:

english

Fichier:

PDF, 738 KB

english, 1990

Differential effects of quinidine on the disposition of nifedipine, sparteine, and mephenytoin in humans

Journal:

van Steveninck, Alfred L, Schoemaker, Hendrik C, Pieters, Monique S M, Kroon, Ria, Breimer, Douwe D, Cohen, Adam F

Année:

1991

Langue:

english

Fichier:

PDF, 1.23 MB

english, 1991

A comparison of the sensitivities of adaptive tracking, eye movement analysis, and visual analog lines to the effects of incremental doses of temazepam in healthy volunteers

Journal:

van Steveninck, Alfred L, Verver, Susanne, Schoemaker, Hendrik C, Pieters, Monique S M, Kroon, Ria, Breimer, Douwe D, Cohen, Adam F

Année:

1991

Langue:

english

Fichier:

PDF, 1.35 MB

english, 1991

Effects of temazepam on saccadic eye movements: Concentration-effect relationships in individual volunteers

Journal:

Mulders, Titia M T, Venizelos, Vicki, Schoemaker, Rik, Cohen, Adam F, Breimer, Douwe D, Mulder, Gerard J

Année:

1992

Langue:

english

Fichier:

PDF, 616 KB

english, 1992

Characterization of glutathione conjugation in humans: Stereoselectivity in plasma elimination pharmacokinetics and urinary excretion of (R)- and (S)-2-bromoisovalerylurea in healthy volunteers

Journal:

Van Steveninck, Alfred L, Schoemaker, Hendrik C, Hartigh, Jan Den, Rijnkels, Jolanda, Pieters, M S M, Breimer, Douwe D, Cohen, Adam F

Année:

1993

Langue:

english

Fichier:

PDF, 707 KB

english, 1993

Effects of intravenous temazepam. I. Saccadic eye movements and electroencephalogram after fast and slow infusion to pseudo steady state

Journal:

Van Steveninck, Alfred L, Schoemaker, Hendrik C, Hartigh, Jan Den, Pieters, M, Breimer, Douwe D, Cohen, Adam F

Année:

1994

Langue:

english

Fichier:

PDF, 1.48 MB

english, 1994

Effects of intravenous temazepam. II. A study of the long-term reproducibility of pharmacokinetics, pharmacodynamics, and concentration-effect parameters

Journal:

Breimer, Michael E., Breimer, Douwe D., Breimer, Lars H.

Année:

1994

Langue:

english

Fichier:

PDF, 1.29 MB

english, 1994

Mobility rethought

Journal:

Nature

Année:

2011

Langue:

english

Fichier:

PDF, 270 KB

english, 2011

P-Glycoprotein Inhibition Leads to Enhanced Disruptive Effects by Anti-Microtubule Cytostatics at the In Vitro Blood-Brain Barrier

Inez C. J. van der Sandt, Pieter J. Gaillard, Heleen H. Voorwinden, Albertus G. de Boer, Douwe D. Breimer

Journal:

Elizabeth C. M. de Lange, Gertjan de Bock, Alfred H. Schinkel, Albertus G. de Boer, Douwe D. Breimer

Année:

2001

Langue:

english

Fichier:

PDF, 198 KB

english, 2001

BBB Transport and P-glycoprotein Functionality Using MDR1A (-/-) and Wild-Type Mice. Total Brain Versus Microdialysis Concentration Profiles of Rhodamine-123

Journal:

Joost B. M. M. van Bree, Corrie D. Heijligers-Feijen, Albertus G. de Boer, Meindert Danhof, Douwe D. Breimer

Année:

1998

Fichier:

PDF, 842 KB

1998

Stereoselective Transport of Baclofen Across the Blood–Brain Barrier in Rats as Determined by the Unit Impulse Response Methodology

Journal:

Ewoud J. van Hoogdalem, Corrie D. Heijligers-Feijen, J. Coos Verhoef, Albertus G. de Boer, Douwe D. Breimer

Année:

1991

Fichier:

PDF, 718 KB

1991

Absorption Enhancement of Rectally Infused Insulin by Sodium Tauro-24,25-Dihydrofusidate (STDHF) in Rats

Journal:

Joost B. M. M. van Bree, Susan Tio, Albertus G. de Boer, J. Coos Verhoef, Douwe D. Breimer

Année:

1990

Fichier:

PDF, 619 KB

1990

Transport of Desglycinamide-Arginine Vasopressin Across the Blood–Brain Barrier in Rats as Evaluated by the Unit Impulse Response Methodology

Journal:

Elizabeth C. M. de Lange, Mayke B. Hesselink, Meindert Danhof, Albertus G. de Boer, Douwe D. Breimer

Année:

1990

Fichier:

PDF, 1.04 MB

1990

The Use of Intracerebral Microdialysis to Determine Changes in Blood-Brain Barrier Transport Characteristics

Journal:

Année:

1995

Fichier:

PDF, 1.02 MB

1995

The Use of Intracerebral Microdialysis for the Determination of Pharmacokinetic Profiles of Anticancer Drugs in Tumor-Bearing Rat Brain

E. C. M. de Lange, J. D. de Vries, C. Zurcher, M. Danhof, A. G. de Boer, Douwe D. Breimer

Journal:

Helga E. de Vries, Elaine F. Eppens, Martine Prins, Johan Kuiper, Theo J. C. van Berkel, Albertus G. de Boer, Douwe D. Breimer

Année:

1995

Fichier:

PDF, 1.87 MB

1995

Transport of a Hydrophilic Compound into the Cerebrospinal Fluid During Experimental Allergic Encephalomyelitis and After Lipopolysaccharide Administration

Journal:

Année:

1995

Fichier:

PDF, 796 KB

1995

Evaluation of Orally Administered Highly Variable Drugs and Drug Formulations

Vinod P. Shah, Avraham Yacobi, William H. Barr, Leslie Z. Benet, Douwe Breimer, Michael R. Dobrinska, Lazslo Endrenyi, William Fairweather, William Gillespie, Mario A. Gonzalez, John Hooper, Andre Jac

Journal:

Mayke B. Hesselink, Bert G. De Boer, Douwe D. Breimer, Wojciech Danysz

Année:

1996

Fichier:

PDF, 1010 KB

1996

Brain Penetration and In Vivo Recovery of NMDA Receptor Antagonists Amantadine and Memantine: A Quantitative Microdialysis Study

Journal:

Henning G. Kristensen, Douwe D. Breimer

Année:

1999

Fichier:

PDF, 945 KB

1999

HANS BUNDGAARD IN MEMORIAM

Journal:

Ulrich Jaehde, Rosalinde Masereeuw, Albertus G. De Boer, Gert Fricker, J. Fred Nagelkerke, J. Vonderscher, Douwe D. Breimer

Année:

1993

Fichier:

PDF, 279 KB

1993

Quantification and Visualization of the Transport of Octreotide, a Somatostatin Analogue, Across Monolayers of Cerebrovascular Endothelial Cells

Journal:

Rosalinde Masereeuw, Ulrich Jaehde, Mariska W. E. Langemeijer, Albertus G. de Boer, Douwe D. Breimer

Année:

1994

Fichier:

PDF, 2.09 MB

1994

In Vitroandin VivoTransport of Zidovudine (AZT) Across the Blood–Brain Barrier and the Effect of Transport Inhibitors

Journal:

Leo G. J. de Leede, Albertus G. de Boer, Siem L. van Velzen, Douwe D. Breimer

Année:

1994

Fichier:

PDF, 1.31 MB

1994

Zero-order rectal delivery of theophylline in man with an osmotic system

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Année:

1982

Langue:

english

Fichier:

PDF, 627 KB

english, 1982

The unit impulse response procedure for the pharmacokinetic evaluation of drug entry into the central nervous system

Joost B. M. M. van Bree, Anne V. Baljet, Anton van Geyt, Albertus G. de Boer, Meindert Danhof, Douwe D. Breimer

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Année:

1989

Langue:

english

Fichier:

PDF, 1.20 MB

english, 1989

Pharmacokinetic modeling of the anticonvulsant response of oxazepam in rats using the pentylenetetrazol threshold concentration as pharmacodynamic measure

Jasper Dingemanse, Frans A. E. Sollie, Douwe D. Breimer, Meindert Danhof

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Année:

1988

Langue:

english

Fichier:

PDF, 1.57 MB

english, 1988

Critical factors of intracerebral microdialysis as a technique to determined the pharmacokinetics of drugs in rat brain

Elizabeth C.M. de Lange, Meindert Danhof, Albertus G. de Boer, Douwe D. Breimer

Journal:

Brain Research

Année:

1994

Langue:

english

Fichier:

PDF, 787 KB

english, 1994

Pharmacokinetic and pharmacodynamic basis for peptide drug delivery system design

Douwe D. Breimer

Journal:

Douwe D. Breimer, J.Coos Verhoef

Année:

1992

Langue:

english

Fichier:

PDF, 672 KB

english, 1992

Guest editorial

Journal:

Douwe D. Breimer, J.Coos Verhoef

Année:

1992

Langue:

english

Fichier:

PDF, 127 KB

english, 1992

Guest editorial

Journal:

Arthur B.J. Noach, Yuji Kurosaki, Margret C.M. Blom-Roosemalen, Albertus G. de Boer, Douwe D. Breimer

Année:

1994

Langue:

english

Fichier:

PDF, 95 KB

english, 1994

Cell-polarity dependent effect of chelation on the paracellular permeability of confluent caco-2 cell monolayers

Journal:

International Journal of Pharmaceutics

Année:

1993

Langue:

english

Fichier:

PDF, 795 KB

english, 1993

Guest editorial

J.Coos Verhoef, Douwe D. Breimer

Journal: